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FDA Warns NSAID Use After 20 Weeks of Pregnancy Could Lead to Complications

In its Drug Safety Communication, dated 10/15/2020, the Food and Drug Administration (FDA) announced that manufacturers of nonsteroidal anti-inflammatory drugs (NSAIDs) will be required to update their labeling to include warnings about potential fetal risk if women take the medications at about 20 weeks or later in their pregnancy. This is of special concern to dentistry since the use of …

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FDA issues warning about dangerous “Benadryl Challenge” seen on social media.

Recently, a “Benadryl Challenge” posted on the social media application TikTok has prompted the U.S. Food and Drug Administration (FDA) to issue a Drug Safety Communication regarding the dangers of consuming larger than recommended doses of the OTC allergy medicine Benadryl®(diphenhydramine). In its Drug Safety Communication, the Agency stated that it was aware of news reports of teenagers presenting in …

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New Asthma Indication for Triple-Ingredient Inhaler May Increase Orosystemic Complications

Recently, the Food and Drug Administration (FDA) approved the supplemental New Drug Application for Trelegy Ellipta® for the maintenance treatment of asthma in patients aged 18 years and older. This new indication is in addition to Trelegy Ellipta®’s previous indication for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. This new indication, and resulting increased market demand, …

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Periodontal Disease and Increased Risk of Colon Cancer

A new study, published in Cancer Prevention Research, indicates that periodontal disease is associated with an increased risk of colorectal cancer. Previous studies have pointed to associations between periodontal disease and other types of cancer. In this study, published in August 2020, researchers prospectively collected information on periodontal disease and tooth loss in participants in the Nurses’ Health Study (1992–2002) …

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Vaping linked to increased COVID-19 risk in teens and young adults

A recent study, published online Aug. 11, 2020 in the Journal of Adolescent Health, found that vaping is linked to a substantially increased risk of COVID-19 among teenagers and young adults. The study, led by researchers at the Stanford University School of Medicine, found that young people who vaped were five times more likely to be infected with COVID-19 than …

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Vitamins and Dietary Supplements For the Prevention of COVID-19?

While evidence continues to support that certain behaviors, such as maintaining a physical distance of 6 feet, wearing a mask, and washing hands frequently are the most effective methods of preventing COVID-19, there remains much information, and misinformation, regarding the use of certain vitamins and dietary supplements to do the same. Recently, the Eastern Virginia Medical School published their “Critical …

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Naloxone Updates

Update: FDA now recommends prescribing naloxone and requires new labeling changes for opioids In its Drug Safety Communication from July 23, 2020, the Food and Drug Administration (FDA) has announced that it recommends that health care professionals consider prescribing naloxone to patients at increased risk of opioid overdose, including those taking benzodiazepines or other CNS depressants, regardless of whether the …

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Azithromycin Use and The Risk of Cardiovascular and Non-Cardiovascular Death

A recent study, published online in JAMA Network Open on June 17, 2020, found a statistically significantly increased relative risk and absolute risk of cardiovascular death and noncardiovascular death with the outpatient use of azithromycin when compared with the use of amoxicillin (an antibiotic not known to increase cardiovascular events) within a five-day window after exposure. Interestingly, the study found an …

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Gabapentinoids and Potential Respiratory Depression with Dental Drugs

The FDA continues to warn practitioners that respiratory depression may occur in patients taking the drugs gabapentin or pregabalin, especially patients who are also predisposed to respiratory depression due to their concomitant use of other respiratory depressants, such as opioid analgesics, and other drugs that depress the central nervous system, such as benzodiazepines. Patients with underlying respiratory disease (such as …

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Opioid Analgesics vs. Non-Opioid Analgesics For Post-Extraction Dental Pain 

A recent study, published in March 2020 in JAMA Network Open, sought to understand the differences in patient-reported outcomes between patients who used opioids and those who did not use opioids after dental procedures, in an effort to encourage the adoption of more conservative and appropriate prescribing practices in dentistry. The study was conducted in the 14 dental clinics of …